Prolonged elevation of serum tryptase resulting from intraoperative anaphylaxis to methylene blue

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Prolonged elevation of serum tryptase resulting from intraoperative anaphylaxis to methylene blue

Background Intraoperative anaphylaxis during sentinel lymph node biopsy is a well known phenomenon occurring with administration of patent blue and isosulfan blue dyes, with an incidence of 2.2% and 1.1%, respectively (1,2). Methylene blue has been reported as being a safer alternative with only a few case reports demonstrating anaphylaxis and large studies demonstrating no incidence of anaphyl...

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[Methylene blue to treat anaphylaxis during anesthesia: case report.].

BACKGROUND AND OBJECTIVES The risk of perioperative anaphylaxis should always be considered. The incidence of anesthetic allergic reactions is controversial, varying from 1/3,000 to 1/20,000, with mortality range between 3 and 9%. This report describes the use of methylene blue as coadjuvant drug to treat anaphylaxis refractory to conventional therapy. CASE REPORT A 53-year-old male patient w...

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Safe thyroidectomy with intraoperative methylene blue spraying

UNLABELLED BACKGROUND We aimed to minimalize operative complications by spraying of methylene blue stain on thyroid glands and the perithyroidal area. MATERIAL AND METHODS The intra-operative methylene blue spraying technique was used prospectively on a total of 56 patients who had undergone primary (not recurrent) thyroid surgery for a variety of thyroid diseases. Bilateral total thyroide...

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Refractory intraoperative hypotension with elevated serum tryptase

Severe intraoperative hypotension has been reported in patients on angiotensin-converting enzyme inhibitors and angiotensin II receptor subtype 1 antagonists. We describe a patient on lisinopril who developed refractory intraoperative hypotension associated with increased serum tryptase level suggesting mast cell activation (allergic reaction). However, allergology workup ruled out an allergic ...

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Anaphylaxis with elevated serum tryptase after administration of intravenous ferumoxytol

Ferumoxytol is a newly approved preparation of intravenous iron with a modified dextran shell that is thought to confer upon it a low immunogenic potential. Serious adverse reactions have been very uncommon in clinical studies, but these studies excluded patients with prior adverse reactions to other preparations of intravenous iron. Furthermore, the reactions were classified clinically. We rep...

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ژورنال

عنوان ژورنال: Allergy, Asthma & Clinical Immunology

سال: 2010

ISSN: 1710-1492

DOI: 10.1186/1710-1492-6-s2-p29